New approaches and challenges to targeting the endocannabinoid system
V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
[HTML][HTML] The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain
G Donvito, SR Nass, JL Wilkerson, ZA Curry… - …, 2018 - nature.com
A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …
various disease states and types of injury. Given that the endogenous cannabinoid (that is …
The cannabinoid system and pain
Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …
Cannabis-based medicines and pain: a review of potential synergistic and entourage effects
U Anand, B Pacchetti, P Anand… - Pain management, 2021 - Taylor & Francis
The recent legalization of medicinal cannabis in several jurisdictions has spurred the
development of therapeutic formulations for chronic pain. Unlike pure delta-9 …
development of therapeutic formulations for chronic pain. Unlike pure delta-9 …
Enhanced endocannabinoid tone as a potential target of pharmacotherapy
M Toczek, B Malinowska - Life sciences, 2018 - Elsevier
The endocannabinoid system is up-regulated in numerous pathophysiological states such
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …
as inflammatory, neurodegenerative, gastrointestinal, metabolic and cardiovascular …
[HTML][HTML] Some prospective alternatives for treating pain: the endocannabinoid system and its putative receptors GPR18 and GPR55
R Guerrero-Alba, P Barragán-Iglesias… - Frontiers in …, 2019 - frontiersin.org
Background: Marijuana extracts (cannabinoids) have been used for several millennia for
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …
pain treatment. Regarding the site of action, cannabinoids are highly promiscuous …
Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential …
L Teixeira-Santos, A Albino-Teixeira, D Pinho - Pharmacological Research, 2020 - Elsevier
Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …
[HTML][HTML] Targeting peripherally restricted cannabinoid receptor 1, cannabinoid receptor 2, and endocannabinoid-degrading enzymes for the treatment of neuropathic …
MZ Hossain, H Ando, S Unno, J Kitagawa - International journal of …, 2020 - mdpi.com
Neuropathic pain conditions including neuropathic orofacial pain (NOP) are difficult to treat.
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …
[HTML][HTML] Cannabinoids modulate neuronal activity and cancer by CB1 and CB2 receptor-independent mechanisms
K Soderstrom, E Soliman, R Van Dross - Frontiers in Pharmacology, 2017 - frontiersin.org
Cannabinoids include the active constituents of Cannabis or are molecules that mimic the
structure and/or function of these Cannabis-derived molecules. Cannabinoids produce …
structure and/or function of these Cannabis-derived molecules. Cannabinoids produce …
[HTML][HTML] Resolvins: potent pain inhibiting lipid mediators via transient receptor potential regulation
Chronic pain is a serious condition that occurs in the peripheral nervous system (PNS) and
the central nervous system (CNS). It is caused by inflammation or nerve damage that …
the central nervous system (CNS). It is caused by inflammation or nerve damage that …