Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

The generation of DNA lesions and the resulting activation of DNA damage response (DDR)
pathways are both affected by the chromatin status at the site of damaged DNA. In turn, DDR …

Molecular mechanisms responsible for hepatocellular carcinoma (HCC) remain largely
unknown. Using genetically engineered mouse models, we show that hepatocyte-specific …

There is virtually no effective treatment for advanced hepatocellular carcinoma (HCC) and
novel targets need to be identified to develop effective treatment. We recently documented …

Cooperative dysregulation of gene sequence and expression may contribute to cancer
formation and progression. The Cancer Genome Atlas (TCGA) Network recently catalogued …

Abstract SND1 is an AEG-1/MTDH/LYRIC-binding protein that is upregulated in numerous
human cancers, where it has been assigned multiple functional roles. In this study, we report …

Plasma membrane proteins that are exposed on the cell surface have important biological
functions, such as signaling into and out of the cells, ion transport, and cell-cell and cell …

Staphylococcal nuclease domain-containing 1 (SND1) is a multifunctional protein that is
overexpressed in multiple cancers, including hepatocellular carcinoma (HCC). Stable …

Abstract KAP1 (TRIM28) is a transcriptional regulator in embryonic development that
controls stem cell self-renewal, chromatin organization, and the DNA damage response …

Esophageal squamous cell carcinoma (ESCC) is among the top ten most frequent
malignancies worldwide. In this study, our objective was to identify potential biomarkers for …