Peptoids and polypeptoids at the frontier of supra-and macromolecular engineering

N Gangloff, J Ulbricht, T Lorson, H Schlaad… - Chemical …, 2016 - ACS Publications
In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

K Rajasekhar, T Govindaraju - RSC advances, 2018 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent, progressive and multifaceted
neurodegenerative disorder associated with cognition, memory and behavioural …

Function and toxicity of amyloid beta and recent therapeutic interventions targeting amyloid beta in Alzheimer's disease

K Rajasekhar, M Chakrabarti… - Chemical …, 2015 - pubs.rsc.org
Amyloidogenesis has been implicated in a broad spectrum of diseases in which amyloid
protein is invariably misfolded and deposited in cells and organs. Alzheimer's disease is one …

Molecular self‐assembly of cyclic dipeptide derivatives and their applications

S Manchineella, T Govindaraju - ChemPlusChem, 2017 - Wiley Online Library
Cyclic dipeptides (CDPs) are heterocyclic 2, 5‐diketopiperazines with exceptional structural
rigidity, enzymatic stability, and biological activity, exhibiting a substantial tendency to take …

Rationally designed peptidomimetic modulators of Aβ toxicity in Alzheimer's disease

K Rajasekhar, SN Suresh, R Manjithaya… - Scientific reports, 2015 - nature.com
Alzheimer's disease is one of the devastating illnesses mankind is facing in the 21st century.
The main pathogenic event in Alzheimer's disease is believed to be the aggregation of the β …

Small molecule inhibits metal-dependent and-independent multifaceted toxicity of Alzheimer's disease

S Samanta, K Rajasekhar, V Babagond… - ACS Chemical …, 2019 - ACS Publications
Alzheimer's disease (AD) is one of the most devastating forms of dementia, without reliable
treatments to cure, delay the onset, or prevent the disease progression. The proposed toxic …

Cyclic dipeptide‐based small molecules modulate zinc‐mediated liquid–liquid phase separation of tau

M Ramesh, C Balachandra, P Baruah… - Journal of Peptide …, 2023 - Wiley Online Library
Liquid–liquid phase separation (LLPS) is a complex physicochemical phenomenon
mediated by multivalent transient weak interactions among macromolecules like polymers …

An overview of peptide and peptoid foldamers in medicinal chemistry

IM Mándity, F Fülöp - Expert opinion on drug discovery, 2015 - Taylor & Francis
Introduction: Foldamers are artificial self-organizing systems with various critical properties:
i) a stable and designable secondary structure; ii) a larger molecular surface as compared …

A sequential Ugi multicomponent/Cu-catalyzed azide–alkyne cycloaddition approach for the continuous flow generation of cyclic peptoids

CEM Salvador, B Pieber, PM Neu… - The Journal of …, 2015 - ACS Publications
The development of a continuous flow multistep strategy for the synthesis of linear peptoids
and their subsequent macrocyclization via Click chemistry is described. The central …

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity

SN Suresh, AK Chavalmane, V Dj, H Yarreiphang… - Autophagy, 2017 - Taylor & Francis
Parkinson disease (PD) is a life-threatening neurodegenerative movement disorder with
unmet therapeutic intervention. We have identified a small molecule autophagy modulator, 6 …