Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide.
Despite sensitivity to androgen deprivation, patients with advanced disease eventually …

Abstract Treatment for solid tumor malignancies, which constitute the majority of human
cancers, is still dominated by surgery and radiotherapies. This is especially true for many …

Autoimmune (AI) diseases can affect many organs; however, the prostate has not been
considered to be a primary target of these systemic inflammatory processes. Here, we utilize …

Tumour necrosis factor (TNF) is a pleiotropic cytokine with dual roles in cancer biology
including prostate cancer (PCa). On the one hand, there is evidence that it stimulates tumour …

Androgen deprivation constitutes the principal therapy for advanced and metastatic prostate
cancers. However, this therapeutic intervention usually results in the transition to a more …

Androgen deficiency plays a crucial role in the pathogenesis of male osteoporosis and
sarcopenia. Myokines have recently been identified as humoral factors that are involved in …

Despite the renal expression of P 2 Y 12, the purinergic receptor for adenosine diphosphate,
few data are available to discuss the renotherapeutic potential of ticagrelor, one of its …

It is currently estimated that inflammatory responses are linked to 15–20% of all deaths from
cancer worldwide. Although many studies point to an important role of inflammation in …

The relationship between cancer and inflammation is one of the most important fields for
both clinical and translational research. Despite numerous studies reported interesting and …

Androgen receptor (AR)-mediated gene expression continues to have a critical role in
promoting castration-resistant prostate cancer (CRPC) survival and growth even after …