Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7
have been recalcitrant to high-resolution structure analysis. However, in the last decade a …

The lysine acetyltransferases play crucial but complex roles in cancer development. GCN5
is a lysine acetyltransferase that generally regulates gene expression, but its role in cancer …

p300/CREB binding protein associated factor (PCAF/KAT2B) and general control
nonderepressible 5 (GCN5/KAT2A) are multidomain proteins that have been implicated in …

Background The development of new biomarkers with diagnostic, prognostic and
therapeutic prominence will greatly enhance the management of breast cancer (BC) …

Histone acetyltransferase GCN5 is a critical component of the TGF‑β/Smad signaling
pathway in breast cancer cells; however, it remains unknown whether it is involved in the …

The general control of nucleotide synthesis 5 (GCN5), which is one kind of lysine
acetyltransferases, regulates a number of cellular processes, such as cell proliferation …

Ada3 protein is an essential component of histone acetyl transferase containing coactivator
complexes conserved from yeast to human. We show here that germline deletion of Ada3 in …

Uncovering mechanisms that regulate ecdysone production is an important step toward
understanding the regulation of insect metamorphosis and processes in steroid-related …

Despite significant research, our understanding of the molecular mechanisms of Human
Papilloma Virus (HPV) induced cancers remains incomplete. Majority of invasive cervical …