Abstract Pharmacokinetic/pharmacodynamic (PK/PD) modelling is the initial step in the semi‐
mechanistic approach for optimizing dosage regimens for systemically acting antimicrobial …

Pharmacokinetic/pharmacodynamic (PK/PD) integration models are used to investigate the
antimicrobial activity characteristics of drugs targeting pathogenic bacteria through …

Florfenicol is a member of the phenicol group, a broad-spectrum antibacterial agent. It has
been used for a long time in veterinary medicine, but there are some factors regarding its …

Although 90% of BRD relapses are reported to receive retreatment with a different class of
antimicrobial, studies examining the impact of antimicrobial selection (ie bactericidal or …

The aims of the present study were to establish optimal doses and provide an alternate
COPD for florfenicol against Streptococcus suis based on pharmacokinetic …

Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict
dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus …

In order to explore the mechanism of liver injury induced by florfenicol (FFC) in broilers, one
hundred and twenty broilers were randomly divided into six groups, twenty broilers in each …

The PK/PD cut-off (PK/PDCO) value of florfenicol for calf pathogens was determined for long
acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of …

Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in
bacterial resistance, clinical treatment failure, and drug residues. To address these …

A major problem of our time is the ever-increasing resistance to antimicrobial agents in
bacterial populations. One of the most effective ways to prevent these problems is to target …