The formation of inclusion bodies (IBs) during expression of recombinant therapeutic
proteins using E. coli is a significant hurdle in producing high-quality, safe, and efficacious …

Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …

Ideonella sakaiensis PET hydrolase (IsPETase) is a well-characterized enzyme for effective
PET biodegradation. However, the low soluble expression level of the enzyme hampers its …

In this study, we introduced a Raman detection technique based on a combination of
functionalized magnetic beads and surface-enhanced Raman scattering (SERS) tags to …

Dynamic light scattering (DLS) is widely used for analyzing biological polymers and colloids.
Its application to nanoparticles in medicine is becoming increasingly important with the …

Protein aggregation is linked to many chronic and devastating neurodegenerative human
diseases and is strongly associated with aging. This work demonstrates that protein …

The pivotal role of proteins in pharmaceuticals is challenged by stability issues, making the
study of inclusion bodies—a source of insoluble protein aggregates—increasingly relevant …

The increase of plastic production together with the incipient reuse/recycling system has
resulted in massive discards into the environment. This has facilitated the formation of micro …

A microsatellite expansion mutation in C9orf72 is the most common genetic cause of
Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). The expansion …

This work describes latent fluorescence particles (LFPs) based on a new environmentally
sensitive carbazole compound aggregated in water and their use as sensors for probing …