Adverse childhood experiences (ACEs) are stressful or potentially traumatic events that
children experience before age 18 years. The term ACEs was coined in 1998 following the …

Curcumin is the major biologically active polyphenolic constituent in the turmeric plant
(Curcuma longa) that has been shown to have antioxidant, anti-inflammatory …

Background Alterations in bidirectional gut–brain interactions are believed to be involved in
the pathogenesis of neuropsychiatric diseases. Considering the putative connections …

There is a growing emphasis on the role of the microbiota-gut-brain axis as modulator of
host behaviour and as therapeutic target for neuropsychiatric disorders. In addition …

Increased exposure to stress is associated with stress-related disorders, including
depression, anxiety, and neurodegenerative conditions. However, susceptibility to stress is …

A novel approach to reduce the incidence of substance use disorders is to promote
resilience to stress using environmental resources such as physical exercise. In the present …

The mammalian brain has high energy demands, which may become higher in response to
environmental challenges such as psychogenic stress exposure. Therefore, efficient …

Pharmacological manipulation of mGluR5 has showed that mGluR5 is implicated in the
pathophysiology of anxiety and mGluR5 has been proposed as a potential drug target for …

Mental health is a global public concern that contributes raising disability and premature
death. Anxiety undertakes around 3.6% of the global population, while psychological stress …

Aim There is a well-founded relation between bullying and depression, which may
eventually lead to suicidal behavior. Repurposing of antidiabetic drugs for the treatment of …