Inefficiency of medical therapies used in order to cure patients with bacterial infections
requires not only to actively look for new therapeutic strategies but also to carefully select …

For years, it has been reported that Alzheimer's disease (AD) is the most common cause of
dementia. Various external and internal factors may contribute to the early onset of AD. This …

Bacterial infections are frequent in cirrhotic patients with acute decompensation or acute-on-
chronic liver failure and can complicate the clinical course. Delayed diagnosis and …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Critically ill patients are at high risk for development of life-threatening infection leading to
sepsis and multiple organ failure. Adequate antimicrobial therapy is pivotal for optimizing the …

The entry of anti-infectives into the central nervous system (CNS) depends on the
compartment studied, molecular size, electric charge, lipophilicity, plasma protein binding …

Infections in critically ill patients are associated with persistently poor clinical outcomes.
These patients have severely altered and variable antibiotic pharmacokinetics and are …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Background β-Lactams are routinely used as empirical therapy in critical illness, with
extended concentrations above the minimum inhibitory concentration (MIC) of the infecting …

Low serum albumin levels are very common in critically ill patients, with reported incidences
as high as 40–50%. This condition appears to be associated with alterations in the degree of …