It is widely accepted that the abnormal self-association of amyloid β-protein (Aβ) is central to
the pathogenesis of Alzheimer's disease, the most common form of dementia. Accumulating …

Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane
regions known as lipid rafts or membrane microdomains. GM1 participates in many …

It is known that oligomers of amyloid-β (Aβ) peptide are associated with Alzheimer's disease.
Aβ has two isoforms: Aβ40 and Aβ42. Although the difference between Aβ40 and Aβ42 is …

The aggregation of amyloid-β protein (Aβ) into oligomers and amyloid fibrils is closely
related to Alzheimer's disease (AD). Aβ40 and Aβ42, as two most prominent isoforms of Aβ …

Alzheimer's disease is understood to be caused by amyloid fibrils and oligomers formed by
aggregated amyloid-β (Aβ) peptides. This review article presents molecular dynamics (MD) …

The aggregation of the amyloid β (Aβ) peptide is one of the molecular hallmarks of
Alzheimer's disease (AD). Although Aβ deposits have mostly been observed extracellularly …

Alzheimer's disease (AD) is associated with progressive accumulation of amyloid-β (Aβ)
cross-β fibrils in the brain. Aβ species tightly associated with GM1 ganglioside, a …

Daptomycin (DP) is effective against multiple drug-resistant Gram-positive pathogens
because of its distinct mechanism of action. An accepted mechanism includes Ca2+ …

Polyalanine (polyA) disease-causative proteins with an expansion of alanine repeats can be
aggregated. Although curative treatments for polyA diseases have not been explored, the …

The cause of Alzheimer's disease is related to aggregates such as oligomers and amyloid
fibrils consisting of amyloid-β (Aβ) peptides. Molecular dynamics (MD) simulation studies …