[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2023 - pmc.ncbi.nlm.nih.gov
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

How computer simulations of the human heart can improve anti‐arrhythmia therapy

NA Trayanova, KC Chang - The Journal of physiology, 2016 - Wiley Online Library
Over the last decade, the state‐of‐the‐art in cardiac computational modelling has
progressed rapidly. The electrophysiological function of the heart can now be simulated with …

Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2024 - journals.physiology.org
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Advances in modeling ventricular arrhythmias: from mechanisms to the clinic

NA Trayanova, PM Boyle - Wiley Interdisciplinary Reviews …, 2014 - Wiley Online Library
Modern cardiovascular research has increasingly recognized that heart models and
simulation can help interpret an array of experimental data and dissect important …

Patterned illumination techniques in optogenetics: an insight into decelerating murine hearts

L Diaz-Maue, J Steinebach, C Richter - Frontiers in Physiology, 2022 - frontiersin.org
Much has been reported about optogenetic based cardiac arrhythmia treatment and the
corresponding characterization of photostimulation parameters, but still, our capacity to …

High-frequency stimulation of excitable cells and networks

SH Weinberg - PLoS One, 2013 - journals.plos.org
High-frequency (HF) stimulation has been shown to block conduction in excitable cells
including neurons and cardiac myocytes. However, the precise mechanisms underlying …

New insights into defibrillation of the heart from realistic simulation studies

NA Trayanova, LJ Rantner - Europace, 2014 - academic.oup.com
Cardiac defibrillation, as accomplished nowadays by automatic, implantable devices,
constitutes the most important means of combating sudden cardiac death. Advancing our …

Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia

HJ Arevalo, PM Boyle, NA Trayanova - Progress in biophysics and …, 2016 - Elsevier
Current understanding of cardiac electrophysiology has been greatly aided by
computational work performed using rabbit ventricular models. This article reviews the …

Optimal entrainment for removal of pinned spiral waves

TS Das, D Wilson - Physical Review E, 2022 - APS
Cardiac fibrillation is caused by self-sustaining spiral waves that occur in the myocardium,
some of which can be pinned to anatomical obstacles, making them more difficult to …

Spiral wave drift induced by high-frequency forcing. Parallel simulation in the Luo–Rudy anisotropic model of cardiac tissue

T Epanchintsev, S Pravdin, A Panfilov - … , Wuxi, China, June 11–13, 2018 …, 2018 - Springer
Non-linear waves occur in various physical, chemical and biological media. One of the most
important examples is electrical excitation waves in the myocardium, which initiate …