Conspectus The field of gene therapy, which aims to treat patients by modulating gene
expression, has come to fruition and has landed several landmark FDA approvals. Most …

Background: Ligand targeted therapy (LTT) is a powerful pharmaceutical strategy to achieve
selective drug delivery to pathological cells, for both therapeutic and diagnostic purposes …

Successful immunogene therapy depends not only on the therapeutic gene but also on the
gene delivery vector. In this study, we synthesized a novel copolymer consisting of low …

Polymer polydispersity, random conjugation of functional groups, and poorly understood
structure–activity relationships have constantly hampered progress in the development of …

A cationic, dendrimer-like oligo (aminoamide) carrier with four-arm topology based on
succinoyl tetraethylene pentamine and histidines, cysteines, and N-terminal azido-lysines …

The asialoglycoprotein receptor (ASGPR) is a high-capacity C-type lectin receptor mainly
expressed on mammalian hepatic cells. The physiological function of ASGPR has not been …

In the era of nucleic acid therapeutics, there is an urgent need for non-viral delivery vehicles
that can cross the extracellular and intracellular barriers and deliver nucleic acids to specific …

An efficient and metal‐catalyst free method of glycopolymer synthesis via thiol/para‐fluorine
“click” reaction was used to graft acetylated 1‐thio‐β‐d‐glucopyranose and 1‐thio‐β‐d …

Regioselective deprotection of acetylated mannose-based mono-and disaccharides
differently functionalized in anomeric position was achieved by enzymatic hydrolysis …

There is an unmet need for simple, reliable, and portable devices for the early detection of
pathogens and toxins. In this research work, we explored the development of a rapid …