Glaucoma is an optic neuropathy that is characterized by the progressive degeneration of
the optic nerve, leading to visual impairment. Glaucoma is the main cause of irreversible …

Genetic and genomic studies, including genome-wide association studies (GWAS) have
accelerated the discovery of genes contributing to glaucoma, the leading cause of …

Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of
childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor …

Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal
ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and …

Juvenile open‐angle glaucoma (JOAG) is a severe type of glaucoma with onset before age
40 and dominant inheritance. Using exome sequencing we identified 3 independent families …

Over the last decade, genetic studies, including genome-wide association studies (GWAS),
have accelerated the discovery of genes and genomic regions contributing to primary open …

Genetic studies have yielded important genes contributing to both early-onset and adult-
onset forms of glaucoma. The proteins encoded by the current collection of glaucoma genes …

Glial cells are critically important for maintenance of neuronal activity in the central nervous
system (CNS), including the optic nerve (ON). However, the ON has several unique …

Purpose: Affecting children by age 3, primary congenital glaucoma (PCG) can cause
debilitating vision loss by the developmental impairment of aqueous drainage resulting in …

Childhood glaucoma is an important cause of blindness world-wide. Eleven genes are
currently known to cause inherited forms of glaucoma with onset before age 20. While all the …