Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and
quality of life. Although ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle …

As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-
competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles …

The Synaptotagmin (SYT) family of proteins play key roles in regulating membrane
trafficking at neuronal synapses. Using both Ca 2+-dependent and Ca 2+-independent …

Abstract Synaptotagmin 7 (SYT7) has emerged as a key regulator of presynaptic function,
but its localization and precise role in the synaptic vesicle cycle remain the subject of …

The balance between fast synchronous and delayed asynchronous release of
neurotransmitters has a major role in defining computational properties of neuronal …

The molecular basis of asynchronous neurotransmitter release remains enigmatic despite
decades of intense study. Synaptotagmin (syt) 7 and Doc2 have both been proposed as …

Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how
coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and …

Sustained cardiac hypertrophy damages the heart and weakens cardiac function, often
leading to heart failure and even death. Pathological cardiac hypertrophy has become a …

Synapses with high release probability (Pr) tend to exhibit short-term synaptic depression.
According to the prevailing model, this reflects the temporary depletion of release-ready …

Behavioral thresholds define the lowest stimulus intensities sufficient to elicit a behavioral
response. Establishment of baseline behavioral thresholds during development is critical for …