Key genes regulating skeletal muscle development and growth in farm animals

M Mohammadabadi, F Bordbar, J Jensen, M Du… - Animals, 2021 - mdpi.com
Simple Summary Skeletal muscle mass is an important economic trait, and muscle
development and growth is a crucial factor to supply enough meat for human consumption …

A comprehensive map of molecular drug targets

R Santos, O Ursu, A Gaulton, AP Bento… - Nature reviews Drug …, 2017 - nature.com
The success of mechanism-based drug discovery depends on the definition of the drug
target. This definition becomes even more important as we try to link drug response to …

[HTML][HTML] Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

SX Lu, E De Neef, JD Thomas, E Sabio, B Rousseau… - Cell, 2021 - cell.com
Although mutations in DNA are the best-studied source of neoantigens that determine
response to immune checkpoint blockade, alterations in RNA splicing within cancer cells …

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

M Li, G Santpere, Y Imamura Kawasawa, OV Evgrafov… - Science, 2018 - science.org
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes
us uniquely human. The development of the brain is a highly complex process, and this …

Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

R Singh, S Chandrashekharappa, SR Bodduluri… - Nature …, 2019 - nature.com
The importance of gut microbiota in human health and pathophysiology is undisputable.
Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in …

CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes

W Wu, P Ji, F Zhao - Genome biology, 2020 - Springer
Existing circular RNA (circRNA) databases have become essential for transcriptomics.
However, most are unsuitable for mining in-depth information for candidate circRNA …

DIANA-TarBase v8: a decade-long collection of experimentally supported miRNA–gene interactions

D Karagkouni, MD Paraskevopoulou… - Nucleic acids …, 2018 - academic.oup.com
Abstract DIANA-TarBase v8 (http://www. microrna. gr/tarbase) is a reference database
devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth …

The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation …

PD Stenson, M Mort, EV Ball, K Evans, M Hayden… - Human genetics, 2017 - Springer
Abstract The Human Gene Mutation Database (HGMD®) constitutes a comprehensive
collection of published germline mutations in nuclear genes that underlie, or are closely …

REVEL: an ensemble method for predicting the pathogenicity of rare missense variants

NM Ioannidis, JH Rothstein, V Pejaver… - The American Journal of …, 2016 - cell.com
The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data …

EnhancerAtlas 2.0: an updated resource with enhancer annotation in 586 tissue/cell types across nine species

T Gao, J Qian - Nucleic acids research, 2020 - academic.oup.com
Enhancers are distal cis-regulatory elements that activate the transcription of their target
genes. They regulate a wide range of important biological functions and processes …