Hemolysis, free hemoglobin toxicity, and scavenger protein therapeutics
F Vallelian, PW Buehler… - Blood, The Journal of the …, 2022 - ashpublications.org
During hemolysis, erythrophagocytes dispose damaged red blood cells. This prevents the
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …
extracellular release of hemoglobin, detoxifies heme, and recycles iron in a linked metabolic …
[HTML][HTML] Rethinking the initial changes in subarachnoid haemorrhage: focusing on real-time metabolism during early brain injury
Over the last two decades, neurological researchers have uncovered many
pathophysiological mechanisms associated with subarachnoid haemorrhage (SAH), with …
pathophysiological mechanisms associated with subarachnoid haemorrhage (SAH), with …
The glymphatic system's role in traumatic brain injury-related neurodegeneration
ME Peters, CG Lyketsos - Molecular psychiatry, 2023 - nature.com
In at least some individuals who suffer a traumatic brain injury (TBI), there exists a risk of
future neurodegenerative illness. This review focuses on the association between the brain …
future neurodegenerative illness. This review focuses on the association between the brain …
Haptoglobin treatment for aneurysmal subarachnoid hemorrhage: review and expert consensus on clinical translation
Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating form of stroke frequently
affecting young to middle-aged adults, with an unmet need to improve outcome. This special …
affecting young to middle-aged adults, with an unmet need to improve outcome. This special …
Targeting hemoglobin to reduce delayed cerebral ischemia after subarachnoid hemorrhage
HA Zeineddine, P Honarpisheh, D McBride… - Translational stroke …, 2022 - Springer
Delayed cerebral ischemia (DCI) continues to be a sequela of aneurysmal subarachnoid
hemorrhage (aSAH) that carries significant morbidity and mortality. Aside from nimodipine …
hemorrhage (aSAH) that carries significant morbidity and mortality. Aside from nimodipine …
[HTML][HTML] Spatial transcriptome analysis defines heme as a hemopexin-targetable inflammatoxin in the brain
After intracranial hemorrhage, heme is released from cell-free hemoglobin. This red blood
cell component may drive secondary brain injury at the hematoma‒brain interface. This …
cell component may drive secondary brain injury at the hematoma‒brain interface. This …
Subarachnoid blood clearance and aneurysmal subarachnoid hemorrhage outcomes: a retrospective review
HA Zeineddine, A Divito, DW McBride, P Pandit… - Neurocritical Care, 2023 - Springer
Background Delayed cerebral ischemia (DCI) continues to be a significant contributor to
morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH) …
morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH) …
[HTML][HTML] Pathophysiology, management, and therapeutics in subarachnoid hemorrhage and delayed cerebral ischemia: an overview
HW Sanicola, CE Stewart, P Luther, K Yabut… - Pathophysiology, 2023 - mdpi.com
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke resulting from the rupture
of an arterial vessel within the brain. Unlike other stroke types, SAH affects both young …
of an arterial vessel within the brain. Unlike other stroke types, SAH affects both young …
Mitochondrial dysfunction and quality control lie at the heart of subarachnoid hemorrhage
J Zhang, Q Zhu, J Wang, Z Peng… - Neural Regeneration …, 2023 - journals.lww.com
The dramatic increase in intracranial pressure after subarachnoid hemorrhage leads to a
decrease in cerebral perfusion pressure and a reduction in cerebral blood flow …
decrease in cerebral perfusion pressure and a reduction in cerebral blood flow …
[HTML][HTML] Clinical potential of automated convolutional neural network-based hematoma volumetry after aneurysmal subarachnoid hemorrhage
BR Thomson, F Gürlek, RM Buzzi… - Journal of Stroke and …, 2023 - Elsevier
Objectives Cerebrospinal fluid hemoglobin has been positioned as a potential biomarker
and drug target for aneurysmal subarachnoid hemorrhage-related secondary brain injury …
and drug target for aneurysmal subarachnoid hemorrhage-related secondary brain injury …