Background Trauma-induced coagulopathy (TIC) is common in trauma patients with major
hemorrhage. Prothrombin complex concentrate (PCC) is used as a potential treatment for …

Uncontrolled and massive bleeding with derangement of coagulation is a major challenge in
the management of both surgical and seriously injured patients. The underlying mechanism …

Objective: The purpose of this study was to compare therapeutic strategies and outcomes,
following isolated gunshot wounds of the head, between military and civilian populations …

We read with interest the paper “Prothrombin complex concentrate (PCC) for treatment of
trauma-induced coagulopathy: systematic review and meta-analyses”[1]. We appreciate our …

Abstract Purpose of Review Early resuscitation with blood products for traumatically injured
patients in hemorrhagic shock represents the current standard of care. Evolving literature …

BACKGROUND Several advancements in hemorrhage control have been advocated for in
the past decade, including balanced transfusions and earlier times to intervention. The aim …

Trauma remains the major cause of years of potential life lost for those less than 44 [1]. It
impacts young and old alike with falls in the elderly being the most common cause of an …

There are three main components manufactured from whole blood: red blood cells (RBCs),
plasma, and platelets. Plasma contains a multitude of different proteins, peptides, and …

Fortunately, there has been a decrease in mortality from trauma over the last five decades,
with a drop of 40% for mortality and a 47.5% decrease in years of potential life lost. Many of …