Oncogenic mutations in KRAS drive common metabolic programmes that facilitate tumour
survival, growth and immune evasion in colorectal carcinoma, non-small-cell lung cancer …

An appropriate control over cell cycle progression depends on many factors. Cyclin-
dependent kinase (CDK) inhibitor p21 (also known as p21 WAF1/Cip1) is one of these …

Breast cancer is one of the most common malignancy among women worldwide. Metastasis
is mainly responsible for treatment failure and is the cause of most breast cancer deaths …

Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated …

Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United
States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it …

After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

Pancreatic ductal adenocarcinoma (PDAC) is a genomically diverse, prevalent, and almost
invariably fatal malignancy. Although conventional genetically engineered mouse models of …

The Hippo–YAP pathway is an emerging signalling cascade involved in the regulation of
stem cell activity and organ size. To identify components of this pathway, we performed an …

Pancreatic cancers arise predominantly from ductal epithelial cells of the exocrine pancreas
and are of the ductal adenocarcinoma histological subtype (PDAC). PDAC is an aggressive …

Pancreatic ductal adenocarcinoma (PDA) develops through distinct precursor lesions,
including pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous …