In the last two decades, evidence from human and animal studies suggests that paternal
obesity around the time of conception can have adverse effects on offspring health through …

Aims This review examined whether maternal and paternal periconceptional nutrition effects
an offspring's likelihood of developing chronic metabolic related conditions due to …

Brown adipocytes dissipate energy, whereas white adipocytes are an energy storage site.
We explored the plasticity of different white adipose tissue depots in acquiring a brown …

Background: Several epidemiologic studies have demonstrated associations between
periconceptional environmental exposures and health status of the offspring in later life …

More than one-half billion people are obese, and despite progress in genetic research,
much of the heritability of obesity remains enigmatic. Here, we identify a Trim28-dependent …

Studies in genetically 'identical'individuals indicate that as much as 50% of complex trait
variation cannot be traced to genetics or to the environment. The mechanisms that generate …

Objective Hundreds of missense mutations in the coding region of PDX1 exist; however, if
these mutations predispose to diabetes mellitus is unknown. Methods In this study, we …

Epigenetics, and in particular imprinted genes, have a critical role in the development and
function of the placenta, which in turn has a central role in the regulation of fetal growth and …

Neuronatin (NNAT) is a transmembrane protein in the endoplasmic reticulum involved in
metabolic regulation. It shares sequence homology with sarcolipin (SLN), which negatively …

The combination of the obesity epidemic and an aging population presents growing
challenges for the healthcare system. Obesity and aging are major risk factors for a diverse …