The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

Neurons in most animals live a very long time relative to the half-lives of all of the proteins
that govern excitability and synaptic transmission. Consequently, homeostatic mechanisms …

Abstract High-conductance,'big'potassium (BK) channels encoded by the Slo gene family
are among the largest and most complex of the extended family of potassium channels. The …

High frequency oscillations (HFO) have a variety of characteristics: band-limited or broad-
band, transient burst-like phenomenon or steady-state. HFOs may be encountered under …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Abstract Episodic ataxia type-2 (EA2) is caused by mutations in P/Q-type voltage-gated
calcium channels that are expressed at high densities in cerebellar Purkinje cells. Because …

Dorsal root ganglion neurons express an array of sodium channel isoforms allowing precise
control of excitability. An increasing body of literature indicates that regulation of firing …

Synaptic inhibition within the hippocampus dentate gyrus serves a'low-pass filtering'function
that protects against hyperexcitability that leads to temporal lobe seizures. Here we …

Large conductance Ca 2+-and voltage-activated K+(BK) channels are widely distributed in
the postnatal central nervous system (CNS). BK channels play a pleiotropic role in …

Neuronal potassium (K+) channels are usually regarded as largely inhibitory, ie reducing
excitability. Here we show that BK‐type calcium‐activated K+ channels enhance high …