Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …

Telomeres play a fundamental role in the protection of chromosomal DNA and in the
regulation of cellular senescence. Recent work in human epidemiology and evolutionary …

Ageing is the predominant risk factor for cardiovascular diseases and contributes to a
significantly worse outcome in patients with acute myocardial infarction. MicroRNAs …

Exceptional genomic stability is one of the hallmarks of mouse embryonic stem (ES) cells.
However, the genes contributing to this stability remain obscure. We previously identified …

Stem cells and cancer cells maintain telomere length mostly through telomerase,,.
Telomerase activity is high in male germ line and stem cells, but is low or absent in mature …

Telomerase, the ribonucleoprotein enzyme maintaining the telomeres of eukaryotic
chromosomes, is active in most human cancers and in germline cells but, with few …

A major limitation of studies of the relevance of telomere length to cancer and age-related
diseases in human populations and to the development of telomere-based therapies has …

The introduction of FISH (fluorescence in situ hybridization) marked the beginning of a new
era for the study of chromosome structure and function. As a combined molecular and …

The loss of telomere repeats has been causally linked to in vitro replicative senescence of
human diploid fibroblasts (HDFs). In order to study the mechanism (s) by which telomere …

Telomeres are involved in the maintenance of chromosomes and the prevention of genome
instability. Despite this central importance, significant variation in telomere length has been …