BACKGROUND Human male infertility has a notable genetic component, including well-
established diagnoses such as Klinefelter syndrome, Y-chromosome microdeletions and …

The spermatozoon is a highly differentiated and polarized cell, with two main structures: the
head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum …

Multiple morphological abnormalities of the sperm flagella (MMAF)-induced
asthenoteratozoospermia is a common cause of male infertility. Previous studies have …

The perinuclear theca (PT) is a cytoskeletal element encapsulating the sperm nucleus;
however, our understanding of the physiological roles of PT in sperm is very limited. We …

STUDY QUESTION What are the causative genetic variants in patients with male infertility
due to severe sperm motility disorders? SUMMARY ANSWER We identified high confidence …

Asthenoteratozoospermia, defined as reduced sperm motility and abnormal sperm
morphology, is a disorder with considerable genetic heterogeneity. Although previous …

Asthenoteratospermia is a common cause of male infertility. Recent studies have revealed
that CFAP65 mutations lead to severe asthenoteratospermia due to acrosome hypoplasia …

Teratozoospermia is a significant cause of male infertility, but the pathogenic mechanism of
acephalic spermatozoa syndrome (ASS), one of the most severe teratozoospermia, remains …

Katanin microtubule-severing enzymes are crucial executers of microtubule regulation.
Here, we have created an allelic loss-of-function series of the katanin regulatory B-subunit …

Male infertility is a heterogeneous condition of largely unknown etiology that affects at least
7% of men worldwide. Classical genetic approaches and emerging next-generation …