In this article strategies for the design and synthesis of natural product analogues are
summarized and illustrated with some selected examples. Proven strategies include …

The molecular chaperone Hsp90 is one component of a highly complex and interactive
cellular proteostasis network (PN) that participates in protein folding, directs misfolded and …

Covering: 2011 to 2021 The structural division of ansamycins, including those of atypical
cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid …

Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid
residue (2, 4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a …

Goblet cell metaplasia, a disabling hallmark of chronic lung disease, lacks curative
treatments at present. To identify novel therapeutic targets for goblet cell metaplasia, we …

Benzenediol lactones are a structurally variable family of fungal polyketide metabolites
possessing a macrolide core structure fused into a resorcinol aromatic ring. These …

The present volume is the third in a trilogy that documents naturally occurring
organohalogen compounds, bringing the total number—from fewer than 25 in 1968—to …

Hsp90 is responsible for the conformational maturation of newly synthesized polypeptides
(client proteins) and the re-maturation of denatured proteins via the Hsp90 chaperone cycle …

Improving the armamentarium to treat invasive candidiasis has become necessary to
overcome drug resistance and the lack of alternative therapy. In the pathogenic fungus …

Pyroptosis is a recently discovered inflammatory form of programmed cell death which is
mostly triggered by infection with intracellular pathogens and critically contributes to …