Tuning the ribosome: the influence of rRNA modification on eukaryotic ribosome biogenesis and function
KE Sloan, AS Warda, S Sharma, KD Entian… - RNA biology, 2017 - Taylor & Francis
ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …
Root of the tree: the significance, evolution, and origins of the ribosome
The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …
Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression
The ribosome, the integration point for protein synthesis in the cell, is conventionally
considered a homogeneous molecular assembly that only passively contributes to gene …
considered a homogeneous molecular assembly that only passively contributes to gene …
History of the ribosome and the origin of translation
We present a molecular-level model for the origin and evolution of the translation system,
using a 3D comparative method. In this model, the ribosome evolved by accretion …
using a 3D comparative method. In this model, the ribosome evolved by accretion …
Peptides before and during the nucleotide world: An origins story emphasizing cooperation between proteins and nucleic acids
SD Fried, K Fujishima, M Makarov… - Journal of the …, 2022 - royalsocietypublishing.org
Recent developments in Origins of Life research have focused on substantiating the
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …
narrative of an abiotic emergence of nucleic acids from organic molecules of low molecular …
Terpenoids and their biosynthesis in cyanobacteria
B Pattanaik, P Lindberg - Life, 2015 - mdpi.com
Terpenoids, or isoprenoids, are a family of compounds with great structural diversity which
are essential for all living organisms. In cyanobacteria, they are synthesized from the …
are essential for all living organisms. In cyanobacteria, they are synthesized from the …
Revisiting the closed-loop model and the nature of mRNA 5′–3′ communication
Summary Communication between the 5′ and 3′ ends of mature eukaryotic mRNAs lies
at the heart of gene regulation, likely arising at the same time as the eukaryotic lineage itself …
at the heart of gene regulation, likely arising at the same time as the eukaryotic lineage itself …
The peptidyl transferase center: a window to the past
MR Tirumalai, M Rivas, Q Tran… - … and Molecular Biology …, 2021 - Am Soc Microbiol
SUMMARY In his 2001 article,“Translation: in retrospect and prospect,” the late Carl Woese
made a prescient observation that there was a need for the then-current view of translation …
made a prescient observation that there was a need for the then-current view of translation …
[HTML][HTML] The emergence of life
E Camprubi, JW De Leeuw, CH House, F Raulin… - Space Science …, 2019 - Springer
The aim of this article is to provide the reader with an overview of the different possible
scenarios for the emergence of life, to critically assess them and, according to the …
scenarios for the emergence of life, to critically assess them and, according to the …
Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions
M Frenkel-Pinter, JW Haynes… - Proceedings of the …, 2019 - National Acad Sciences
Numerous long-standing questions in origins-of-life research center on the history of
biopolymers. For example, how and why did nature select the polypeptide backbone and …
biopolymers. For example, how and why did nature select the polypeptide backbone and …