[HTML][HTML] Targeting immunoregulation for cardiac regeneration
R Li, C Xiang, Y Li, Y Nie - Journal of Molecular and Cellular Cardiology, 2023 - Elsevier
Inducing endogenous cardiomyocyte proliferation and heart regeneration is a promising
strategy to treat ischemic heart failure. The immune response has recently been considered …
strategy to treat ischemic heart failure. The immune response has recently been considered …
CCND2 modified mRNA activates cell cycle of cardiomyocytes in hearts with myocardial infarction in mice and pigs
BACKGROUND: Experiments in mammalian models of cardiac injury suggest that the
cardiomyocyte-specific overexpression of CCND2 (cyclin D2, in humans) improves recovery …
cardiomyocyte-specific overexpression of CCND2 (cyclin D2, in humans) improves recovery …
Analysis of cardiac single-cell RNA-sequencing data can be improved by the use of artificial-intelligence-based tools
Single-cell RNA sequencing (scRNAseq) enables researchers to identify and characterize
populations and subpopulations of different cell types in hearts recovering from myocardial …
populations and subpopulations of different cell types in hearts recovering from myocardial …
[HTML][HTML] Promoting cardiomyocyte proliferation for myocardial regeneration in large mammals
From molecular and cellular perspectives, heart failure is caused by the loss of
cardiomyocytes—the fundamental contractile units of the heart. Because mammalian …
cardiomyocytes—the fundamental contractile units of the heart. Because mammalian …
Integrated proteomics reveals alterations in sarcomere composition and developmental processes during postnatal swine heart development
The neonatal swine heart possesses an endogenous ability to regenerate injured
myocardium through the proliferation of pre-existing cardiomyocyte (CM) populations …
myocardium through the proliferation of pre-existing cardiomyocyte (CM) populations …
Cardiomyocyte Cell-Cycle Regulation in Neonatal Large Mammals: Single Nucleus RNA-Sequencing Data Analysis via an Artificial-Intelligence–Based Pipeline
Adult mammalian cardiomyocytes have very limited capacity to proliferate and repair the
myocardial infarction. However, when apical resection (AR) was performed in pig hearts on …
myocardial infarction. However, when apical resection (AR) was performed in pig hearts on …
WINNER: A network biology tool for biomolecular characterization and prioritization
Background and contribution In network biology, molecular functions can be characterized
by network-based inference, or “guilt-by-associations.” PageRank-like tools have been …
by network-based inference, or “guilt-by-associations.” PageRank-like tools have been …
[HTML][HTML] Cell-cycle–specific autoencoding improves cluster analysis of cycling cardiomyocytes
Background Our previous analyses of cardiomyocyte single-nucleus RNA sequencing
(snRNAseq) data from the hearts of fetal pigs and pigs that underwent apical resection …
(snRNAseq) data from the hearts of fetal pigs and pigs that underwent apical resection …
Follistatin From hiPSC-Cardiomyocytes Promotes Myocyte Proliferation in Pigs With Postinfarction LV Remodeling
BACKGROUND: When human induced pluripotent stem cells (hiPSCs) that CCND2-OE
(overexpressed cyclin-D2) were differentiated into cardiomyocytes (CCND2-OEhiPSC-CMs) …
(overexpressed cyclin-D2) were differentiated into cardiomyocytes (CCND2-OEhiPSC-CMs) …
Single-cell RNA sequencing analysis identifies one subpopulation of endothelial cells that proliferates and another that undergoes the endothelial-mesenchymal …
Background: In our previous work, we demonstrated that when newborn pigs undergo apical
resection (AR) on postnatal day 1 (P1), the animals' hearts were completely recover from a …
resection (AR) on postnatal day 1 (P1), the animals' hearts were completely recover from a …