Centrosomes are the main microtubule-organizing centres, playing essential roles in the
organization of the cytoskeleton during interphase, and in the mitotic spindle, which controls …

Centrosomes were first described by Edouard Van Beneden and named and linked to
chromosome segregation by Theodor Boveri around 1870. In the 1960–1980s, electron …

Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. A
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …

Centrioles are microtubule-based cell organelles present in most eukaryotes. They
participate in the control of cell division as part of the centrosome, the major microtubule …

Estrogens are associated with a variety of diseases and play important roles in tumor
development and progression. Centrosome defects are hallmarks of human cancers and …

Primary cilia mediate sensory signaling in multiple organisms and cell types but have
structures adapted for specific roles. Structural defects in them lead to devastating diseases …

Directed cell migration requires sustained cell polarisation. In migrating cortical
interneurons, nuclear movements are directed towards the centrosome that organises the …

The centrosome is a tiny cytoplasmic organelle that organizes and constructs massive
molecular machines to coordinate diverse cellular processes. Due to its many roles during …

Several biological macromolecules, such as proteins, nucleic acids, and polysaccharides,
occupy about 30% of the space in cells, resulting in a crowded macromolecule environment …

Defects in primary or motile cilia result in a variety of human pathologies, and retinal
degeneration is frequently associated with these so-called ciliopathies. We found that …