Abstract Background The Infectious Diseases Society of America (IDSA) is committed to
providing up-to-date guidance on the treatment of antimicrobial-resistant (AMR) infections …

Hypoalbuminemia is associated with the acquisition and severity of infectious diseases, and
intact innate and adaptive immune responses depend on albumin. Albumin oxidation and …

Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Purpose Cisplatin-associated acute kidney injury (C-AKI) is common. We sought to develop
and validate a predictive model for C-AKI after the first course of cisplatin. Methods Clinical …

The liver is the primary site of drug metabolism, which can be altered by a variety of
diseases affecting the liver parenchyma, especially in patients with liver cirrhosis. The use of …

The use of ceftriaxone, a highly protein-bound drug, in the setting of hypoalbuminemia may
result in suboptimal drug exposure. Patients with obesity also exhibit higher absolute drug …

Infections are important factors contributing to the morbidity and mortality among elderly
patients. High rates of consumption of antimicrobial agents by the elderly may result in …

Bacterial infections frequently cause decompensating events in cirrhotic patients and are
also the most common factor identified for the development of acute-on-chronic liver failure …

Background Bloodstream infections caused by MSSA are associated with significant
morbidity and mortality. Traditional treatment of MSSA bacteraemia includes an IV …

Introduction The importance of antibiotic treatment for sepsis in critically ill septic patients is
well established. Consistently achieving the dose of antibiotics required to optimally kill …