Aims To examine the literature on the associations between alcohol use disorders (AUD)
and major depression (MD), and to evaluate the evidence for the existence of a causal …

Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …

The neural networks that putatively modulate aspects of normal emotional behavior have
been implicated in the pathophysiology of mood disorders by converging evidence from …

Objective To present nationally representative data on 12-month and lifetime prevalence,
correlates, and comorbidity ofDSM-IVmajor depressive disorder (MDD) among adults in the …

Genetic variation may partially underlie complex personality and physiological traits—such
as impulsivity, risk taking and stress responsivity—as well as a substantial proportion of …

During the last decade, several studies have shown that insomnia, rather than a symptom of
depression, could be a medical condition on its own, showing high comorbidity with …

Context The need for improved therapeutic agents that more quickly and effectively treat
depression is critical. In a pilot study we evaluated the role of the cholinergic system in …

There has been an explosion of interest in studying gene-environment interactions (GxE) as
they relate to the development of psychopathology. In this article, I review different …

Abstract Background and Aims Alcohol use disorders (AUD) are often comorbid with
depressive symptoms. Cohort studies on the association between AUD and subsequent …

Now revised and updated, this widely used text comprehensively reviews theories of
addiction to give students and professionals a multidisciplinary foundation for clinical …