Immunodepression, infections, and functional outcome in ischemic stroke

WF Westendorp, C Dames, PJ Nederkoorn, A Meisel - Stroke, 2022 - Am Heart Assoc
Stroke remains one of the main causes of mortality and morbidity worldwide. Immediately
after stroke, a neuroinflammatory process starts in the brain, triggering a systemic …

Liquid biopsy in neurological diseases

S Malhotra, MCM Miras, A Pappolla, X Montalban… - Cells, 2023 - mdpi.com
The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …

miRTargetLink 2.0—interactive miRNA target gene and target pathway networks

F Kern, E Aparicio-Puerta, Y Li, T Fehlmann… - Nucleic acids …, 2021 - academic.oup.com
Which genes, gene sets or pathways are regulated by certain miRNAs? Which miRNAs
regulate a particular target gene or target pathway in a certain physiological context …

Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults

Z Kovarik, G Moshitzky, N Maček Hrvat… - Journal of …, 2024 - Wiley Online Library
This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …

Regulators of cholinergic signaling in disorders of the central nervous system

K Winek, H Soreq, A Meisel - Journal of Neurochemistry, 2021 - Wiley Online Library
Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …

Circulating non-coding RNAs in chronic kidney disease and its complications

AJ van Zonneveld, Q Zhao, JI Rotmans… - Nature Reviews …, 2023 - nature.com
Post-transcriptional regulation by non-coding RNAs (ncRNAs) can modulate the expression
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …

Role of the cholinergic anti-inflammatory reflex in central nervous system diseases

IE Ramos-Martínez, MC Rodríguez, M Cerbón… - International Journal of …, 2021 - mdpi.com
In several central nervous system diseases, it has been reported that inflammation may be
related to the etiologic process, therefore, therapeutic strategies are being implemented to …

miRMaster 2.0: multi-species non-coding RNA sequencing analyses at scale

T Fehlmann, F Kern, O Laham, C Backes… - Nucleic acids …, 2021 - academic.oup.com
Analyzing all features of small non-coding RNA sequencing data can be demanding and
challenging. To facilitate this process, we developed miRMaster. After the analysis of over …

Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease‐related changes

I Paldor, N Madrer, S Vaknine Treidel… - Journal of …, 2023 - Wiley Online Library
Transfer RNA fragments (tRFs) have recently been shown to be an important family of small
regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood …

The tRNA regulome in neurodevelopmental and neuropsychiatric disease

J Blaze, S Akbarian - Molecular psychiatry, 2022 - nature.com
Abstract Transfer (t) RNAs are 70–90 nucleotide small RNAs highly regulated by 43 different
types of epitranscriptomic modifications and requiring aminoacylation ('charging') for mRNA …