Immunodepression, infections, and functional outcome in ischemic stroke
WF Westendorp, C Dames, PJ Nederkoorn, A Meisel - Stroke, 2022 - Am Heart Assoc
Stroke remains one of the main causes of mortality and morbidity worldwide. Immediately
after stroke, a neuroinflammatory process starts in the brain, triggering a systemic …
after stroke, a neuroinflammatory process starts in the brain, triggering a systemic …
Liquid biopsy in neurological diseases
S Malhotra, MCM Miras, A Pappolla, X Montalban… - Cells, 2023 - mdpi.com
The most recent and non-invasive approach for studying early-stage biomarkers is liquid
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …
biopsy. This implies the extraction and analysis of non-solid biological tissues (serum …
miRTargetLink 2.0—interactive miRNA target gene and target pathway networks
Which genes, gene sets or pathways are regulated by certain miRNAs? Which miRNAs
regulate a particular target gene or target pathway in a certain physiological context …
regulate a particular target gene or target pathway in a certain physiological context …
Recent advances in cholinergic mechanisms as reactions to toxicity, stress, and neuroimmune insults
Z Kovarik, G Moshitzky, N Maček Hrvat… - Journal of …, 2024 - Wiley Online Library
This review presents recent studies of the chemical and molecular regulators of
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …
acetylcholine (ACh) signaling and the complexity of the small molecule and RNA regulators …
Regulators of cholinergic signaling in disorders of the central nervous system
Cholinergic signaling is crucial in cognitive processes, and degenerating cholinergic
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …
projections are a pathological hallmark in dementia. Use of cholinesterase inhibitors is …
Circulating non-coding RNAs in chronic kidney disease and its complications
AJ van Zonneveld, Q Zhao, JI Rotmans… - Nature Reviews …, 2023 - nature.com
Post-transcriptional regulation by non-coding RNAs (ncRNAs) can modulate the expression
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …
of genes involved in kidney physiology and disease. A large variety of ncRNA species exist …
Role of the cholinergic anti-inflammatory reflex in central nervous system diseases
IE Ramos-Martínez, MC Rodríguez, M Cerbón… - International Journal of …, 2021 - mdpi.com
In several central nervous system diseases, it has been reported that inflammation may be
related to the etiologic process, therefore, therapeutic strategies are being implemented to …
related to the etiologic process, therefore, therapeutic strategies are being implemented to …
miRMaster 2.0: multi-species non-coding RNA sequencing analyses at scale
Analyzing all features of small non-coding RNA sequencing data can be demanding and
challenging. To facilitate this process, we developed miRMaster. After the analysis of over …
challenging. To facilitate this process, we developed miRMaster. After the analysis of over …
Cerebrospinal fluid and blood profiles of transfer RNA fragments show age, sex, and Parkinson's disease‐related changes
Transfer RNA fragments (tRFs) have recently been shown to be an important family of small
regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood …
regulatory RNAs with diverse functions. Recent reports have revealed modified tRF blood …
The tRNA regulome in neurodevelopmental and neuropsychiatric disease
J Blaze, S Akbarian - Molecular psychiatry, 2022 - nature.com
Abstract Transfer (t) RNAs are 70–90 nucleotide small RNAs highly regulated by 43 different
types of epitranscriptomic modifications and requiring aminoacylation ('charging') for mRNA …
types of epitranscriptomic modifications and requiring aminoacylation ('charging') for mRNA …