[HTML][HTML] Capturing the conversion of the pathogenic alpha-1-antitrypsin fold by ATF6 enhanced proteostasis
Genetic variation in alpha-1 antitrypsin (AAT) causes AAT deficiency (AATD) through liver
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …
[HTML][HTML] Leveraging population genomics for individualized correction of the hallmarks of alpha-1 antitrypsin deficiency
Deep medicine is rapidly moving towards a high-definition approach for therapeutic
management of the patient as an individual given the rapid progress of genome sequencing …
management of the patient as an individual given the rapid progress of genome sequencing …
[HTML][HTML] Tracing genetic diversity captures the molecular basis of misfolding disease
Genetic variation in human populations can result in the misfolding and aggregation of
proteins, giving rise to systemic and neurodegenerative diseases that require management …
proteins, giving rise to systemic and neurodegenerative diseases that require management …
Profiling genetic diversity reveals the molecular basis for balancing function with misfolding in alpha-1 antitrypsin
Genetic variation of alpha-1 antitrypsin (AAT) is responsible for alpha-1-antitrypsin
deficiency (AATD) leading to gain-of-toxic aggregation in the liver and loss-of-function on n …
deficiency (AATD) leading to gain-of-toxic aggregation in the liver and loss-of-function on n …
[图书][B] Measuring the effect of histone deacetylase inhibitors (HDACi) on the secretion and activity of alpha-1 antitrypsin
C Wang, M Bouchecareilh, WE Balch - 2017 - Springer
Abstract Alpha-1 antitrypsin deficiency (AATD) is a protein conformational disease with the
most common cause being the Z-variant mutation in alpha-1 antitrypsin (Z-AAT). The …
most common cause being the Z-variant mutation in alpha-1 antitrypsin (Z-AAT). The …
Gaussian Process Captures the Conversion of the Pathogenic Alpha-1-Antitrypsin Fold by ATF6 Enhanced Proteostasis
S Sun, C Wang, P Zhao, G Kline… - Available at SSRN …, 2022 - papers.ssrn.com
Genetic variation in alpha-1 antitrypsin (AAT) causes AAT deficiency (AATD) through liver
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …