Microfluidics, a technology characterized by the engineered manipulation of fluids at the
submillimetre scale, has shown considerable promise for improving diagnostics and biology …

Neutrophils have long been viewed as the final effector cells of an acute inflammatory
response, with a primary role in the clearance of extracellular pathogens. However, more …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Separation of cells is a critical process for studying cell properties, disease diagnostics, and
therapeutics. Cell sorting by acoustic waves offers a means to separate cells on the basis of …

Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the
experienced intensivist as a “complicated clinical course” and is frequently attributed to …

As the integration of microfluidics into cell biology research proceeds at an ever-increasing
pace, a critical question for those working at the interface of both disciplines is which device …

Background The specialisation of mammalian cells in time and space requires genes
associated with specific pathways and functions to be co-ordinately expressed. Here we …

Rationale: Using microarray data, we previously identified gene expression–based
subclasses of septic shock with important phenotypic differences. The subclass-defining …

In recognition of the enormous potential of immunotherapies against cancer, research into
the interactions between tumor and immune cells has accelerated, leading to the recent FDA …

In hematologic diseases, such as sickle cell disease (SCD) and hemolytic uremic syndrome
(HUS), pathological biophysical interactions among blood cells, endothelial cells, and …