The role of cytochrome P450s in insect toxicology and resistance

R Nauen, C Bass, R Feyereisen… - Annual Review of …, 2022 - annualreviews.org
Insect cytochrome P450 monooxygenases (P450s) perform a variety of important
physiological functions, but it is their role in the detoxification of xenobiotics, such as natural …

Phylogenomic and functional characterization of an evolutionary conserved cytochrome P450-based insecticide detoxification mechanism in bees

J Haas, A Hayward, B Buer… - Proceedings of the …, 2022 - National Acad Sciences
The regulatory process for assessing the risks of pesticides to bees relies heavily on the use
of the honeybee, Apis mellifera, as a model for other bee species. However, the validity of …

The molecular determinants of pesticide sensitivity in bee pollinators

C Bass, A Hayward, BJ Troczka, J Haas… - Science of the Total …, 2024 - Elsevier
Bees carry out vital ecosystem services by pollinating both wild and economically important
crop plants. However, while performing this function, bee pollinators may encounter …

Does pesticide use in agriculture present a risk to the terrestrial biota?

DBN Kenko, NT Ngameni, ME Awo, NA Njikam… - Science of the Total …, 2023 - Elsevier
Inadequate pesticide application practices have many implications on human and
environmental health. This research aimed at assessing pesticide risks on bees, non-target …

Mixture toxic effects of thiacloprid and cyproconazole on honey bees (Apis mellifera L.)

L Lv, W Li, X Li, D Wang, H Weng, YC Zhu… - Science of the Total …, 2023 - Elsevier
Pesticide exposure remains one of the main factors in the population decline of insect
pollinators. It is urgently necessary to assess the effects of mixtures on pollinator risk …

Intra-specific variation in sensitivity of Bombus terrestris and Osmia bicornis to three pesticides

A Linguadoca, M Jürison, S Hellström, EA Straw… - Scientific Reports, 2022 - nature.com
There is growing evidence that pesticides may be among the causes of worldwide bee
declines, which has resulted in repeated calls for their increased scrutiny in regulatory …

[HTML][HTML] A toxicogenomics approach reveals characteristics supporting the honey bee (Apis mellifera L.) safety profile of the butenolide insecticide flupyradifurone

J Haas, M Zaworra, J Glaubitz, G Hertlein… - Ecotoxicology and …, 2021 - Elsevier
Flupyradifurone, a novel butenolide insecticide, selectively targets insect nicotinic
acetylcholine receptors (nAChRs), comparable to structurally different insecticidal …

[HTML][HTML] Expression profile of the entire detoxification gene inventory of the western honeybee, Apis mellifera across life stages

F Maiwald, J Haas, G Hertlein, B Lueke… - Pesticide Biochemistry …, 2023 - Elsevier
The western honeybee, Apis mellifera, is a managed pollinator of many crops and
potentially exposed to a wide range of foreign compounds, including pesticides throughout …

A mechanism‐based approach unveils metabolic routes potentially mediating chlorantraniliprole synergism in honey bees, Apis mellifera L., by azole fungicides

J Haas, J Glaubitz, U Koenig… - Pest Management …, 2022 - Wiley Online Library
BACKGROUND Almond production in California is an intensively managed agroecosystem
dependent on managed pollination by honey bees, Apis mellifera L. A recent laboratory …

Pollution status, influencing factors and environmental risks of neonicotinoids, fipronil and its metabolites in a typical semi-closed bay in China

X He, J Chen, X Li, J Wang, M Xin, X Sun, W Cao… - Environmental …, 2021 - Elsevier
The occurrence, spatiotemporal variations, influence factors and environmental risks of eight
common neonicotinoids (NEOs), fipronil, and three fipronil metabolites (fipronil and its …