Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary
kidney disease and one of the most common causes of end-stage kidney disease. Multiple …

Primary cilia are specialized sensory organelles that protrude from the apical surface of most
cell types. Over the past two decades, they have been found to play important roles in tissue …

Approval of the vasopressin V2 receptor antagonist tolvaptan—based on the landmark
TEMPO 3: 4 trial—marked a transformation in the management of autosomal dominant …

Autosomal dominant polycystic kidney disease is one of the most common hereditary
disorders, being 10 times more common than sickle cell disease, 15 times more common …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited
cause of kidney failure, accounting for 5%-10% of cases. Predicting which patients with …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by growth of
kidney cysts and glomerular filtration rate (GFR) decline. Metformin was found to impact …

Targeting the collecting duct water channel aquaporin 2 (AQP2) to the plasma membrane is
essential for the maintenance of mammalian water homeostasis. The vasopressin V2 …

Nanoparticle drug delivery has many advantages over small molecule therapeutics,
including reducing off-target side effects and increasing drug potency. However, many …

Oxidative stress is emerging as a crucial contributor to the pathogenesis of autosomal
dominant polycystic kidney disease (ADPKD), but the molecular mechanisms underlying the …