Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review
The early-life social environment can induce stable changes that influence
neurodevelopment and mental health. Research focused on early-life adversity revealed …
neurodevelopment and mental health. Research focused on early-life adversity revealed …
Advanced cell culture techniques for cancer drug discovery
CJ Lovitt, TB Shelper, VM Avery - Biology, 2014 - mdpi.com
Human cancer cell lines are an integral part of drug discovery practices. However, modeling
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
the complexity of cancer utilizing these cell lines on standard plastic substrata, does not …
Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility
LE Reinius, N Acevedo, M Joerink, G Pershagen… - PloS one, 2012 - journals.plos.org
Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …
measured by a large number of methods, now even in a genome-wide manner for hundreds …
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition
Although the function of DNA methylation in gene promoter regions is well established in
transcriptional repression, the function of the evolutionarily conserved widespread …
transcriptional repression, the function of the evolutionarily conserved widespread …
Caloric restriction delays age-related methylation drift
In mammals, caloric restriction consistently results in extended lifespan. Epigenetic
information encoded by DNA methylation is tightly regulated, but shows a striking drift …
information encoded by DNA methylation is tightly regulated, but shows a striking drift …
The molecular bases of the suicidal brain
G Turecki - Nature Reviews Neuroscience, 2014 - nature.com
Suicide ranks among the leading causes of death around the world and takes a heavy
emotional and public health toll on most societies. Both distal and proximal factors contribute …
emotional and public health toll on most societies. Both distal and proximal factors contribute …
Tet family proteins and 5-hydroxymethylcytosine in development and disease
L Tan, YG Shi - Development, 2012 - journals.biologists.com
Over the past few decades, DNA methylation at the 5-position of cytosine (5-methylcytosine,
5mC) has emerged as an important epigenetic modification that plays essential roles in …
5mC) has emerged as an important epigenetic modification that plays essential roles in …
Prenatal maternal stress predicts methylation of genes regulating the hypothalamic–pituitary–adrenocortical system in mothers and newborns in the Democratic …
Exposure to stress early in life permanently shapes activity of the hypothalamic–pituitary–
adrenocortical (HPA) axis and the brain. Prenatally, glucocorticoids pass through the …
adrenocortical (HPA) axis and the brain. Prenatally, glucocorticoids pass through the …
Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type
Background Individual genotypes at specific loci can result in different patterns of DNA
methylation. These methylation quantitative trait loci (meQTLs) influence methylation across …
methylation. These methylation quantitative trait loci (meQTLs) influence methylation across …
Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array
Background DNA methylation has been recognized as a key mechanism in cell
differentiation. Various studies have compared tissues to characterize epigenetically …
differentiation. Various studies have compared tissues to characterize epigenetically …