Molecular mechanisms and future implications of VEGF/VEGFR in cancer therapy

SA Patel, MB Nilsson, X Le, T Cascone, RK Jain… - Clinical Cancer …, 2023 - AACR
Angiogenesis, the sprouting of new blood vessels from existing vessels, is one of six known
mechanisms employed by solid tumors to recruit blood vessels necessary for their initiation …

[HTML][HTML] The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF

S Ghalehbandi, J Yuzugulen, MZI Pranjol… - European Journal of …, 2023 - Elsevier
Angiogenesis is a double-edged sword; it is a mechanism that defines the boundary
between health and disease. In spite of its central role in physiological homeostasis, it …

[HTML][HTML] Brown-fat-mediated tumour suppression by cold-altered global metabolism

T Seki, Y Yang, X Sun, S Lim, S Xie, Z Guo, W Xiong… - Nature, 2022 - nature.com
Glucose uptake is essential for cancer glycolysis and is involved in non-shivering
thermogenesis of adipose tissues,,,,–. Most cancers use glycolysis to harness energy for …

A concise review of VEGF, PDGF, FGF, Notch, angiopoietin, and HGF signalling in tumor angiogenesis with a focus on alternative approaches and future directions

S Vimalraj - International Journal of Biological Macromolecules, 2022 - Elsevier
Angiogenesis forms new vessels from existing ones. Abnormal angiogenesis, which is what
gives tumor microenvironments their distinctive features, is characterised by convoluted …

Brain‐targeted HFn‐Cu‐rego nanoplatform for site‐specific delivery and manipulation of autophagy and cuproptosis in glioblastoma

W Jia, H Tian, J Jiang, L Zhou, L Li, M Luo, N Ding… - Small, 2023 - Wiley Online Library
Durable glioblastoma multiforme (GBM) management requires long‐term chemotherapy
after surgery to eliminate remaining cancerous tissues. Among chemotherapeutics …

Targeting angiogenesis in breast cancer: current evidence and future perspectives of novel anti-angiogenic approaches

NM Ayoub, SK Jaradat, KM Al-Shami… - Frontiers in …, 2022 - frontiersin.org
Angiogenesis is a vital process for the growth and dissemination of solid cancers. Numerous
molecular pathways are known to drive angiogenic switch in cancer cells promoting the …

Novel drugs with high efficacy against tumor angiogenesis

S Qi, S Deng, Z Lian, K Yu - International Journal of Molecular Sciences, 2022 - mdpi.com
Angiogenesis is involved in physiological and pathological processes in the body. Tumor
angiogenesis is a key factor associated with tumor growth, progression, and metastasis …

Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy

K Wang, S Fu, L Dong, D Zhang, M Wang, X Wu… - Autophagy, 2023 - Taylor & Francis
Colorectal cancer (CRC) is one of the most common malignancies worldwide and remains a
major clinical challenge. Periplocin, a major bioactive component of the traditional Chinese …

Bacterial‐Mediated Tumor Therapy: Old Treatment in a New Context

Y Liu, L Niu, N Li, Y Wang, M Liu, X Su, X Bao… - Advanced …, 2023 - Wiley Online Library
Targeted therapy and immunotherapy have brought hopes for precision cancer treatment.
However, complex physiological barriers and tumor immunosuppression result in poor …

Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer

C Francavilla, CS O'Brien - Open Biology, 2022 - royalsocietypublishing.org
Fibroblast Growth Factor Receptor (FGFR) signalling plays a critical role in breast embryonal
development, tissue homeostasis, tumorigenesis and metastasis. FGFR, its numerous FGF …