Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of the nuclear hormone receptor superfamily. The 3 PPAR isoforms (alpha, delta/beta …

Cerebral ischemia/reperfusion (I/R) injury triggers multiple and distinct but overlapping cell
signaling pathways, which may lead to cell survival or cell damage. There is overwhelming …

The effects of photothrombotic stroke in primary somatosensory cortex on astroglial and
microglial activation in various regions of lesioned brain were examined at different time …

Stroke is a leading cause of death and long-term disability in industrialized countries.
Despite advances in understanding its pathophysiology, little progress has been made in …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, rosiglitazone, not only
improves insulin resistance in patients with type II diabetes but also exerts a broad spectrum …

Occupational exposure and experimental intoxication with acrylamide (ACR) produce a
neuropathy characterized by nerve degeneration. We hypothesize that ACR differentially …

Background: Glucose/serum deprivation (GSD), has been used for understanding molecular
mechanisms of neuronal damage during ischemia. It has been suggested that curcumin may …

Background: Neuroprotection is a major therapeutic approach for ischemic brain injury. We
investigated the neuroprotective effects induced by transplantation of human embryonic …

Stroke and perinatal asphyxia have detrimental effects on neuronal cells, causing millions of
deaths worldwide each year. Since currently available therapies are insufficient, there is an …

Background: Adriamycin (ADR) induced heart failure is associated with an increase in
oxidative stress and apoptosis. Changes due to ADR in mitogen-activated protein kinases …