We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …

Bacteriophages have important roles in the ecology of the human gut microbiome but are
under-represented in reference databases. To address this problem, we assembled the …

The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …

Over the past few decades, the interest in lactic acid bacteria (LAB) has been steadily
growing. This is mainly due to their industrial use, their health benefits as probiotic bacteria …

Background Double-stranded DNA bacteriophages (dsDNA phages) play pivotal roles in
structuring human gut microbiomes; yet, the gut virome is far from being fully characterized …

Despite the accelerating number of uncultivated virus sequences discovered in
metagenomics and their apparent importance for health and disease, the human gut virome …

Due to technical limitations, most gut microbiome studies have focused on prokaryotes,
overlooking viruses. Phanta, a virome-inclusive gut microbiome profiling tool, overcomes the …

The development of clustered regularly interspaced short-palindromic repeat (CRISPR)-Cas
systems for genome editing has transformed the way life science research is conducted and …

Bacteriophages are key components of gut microbiomes, yet the phage colonization process
in the infant gut remains uncertain. Here, we establish a large phage sequence database …

For any given bacteriophage genome or phage-derived sequences in metagenomic data
sets, we are unable to assign a function to 50–90% of genes, or more. Structural protein …