Mechanisms and clinical importance of bacteriophage resistance
JE Egido, AR Costa… - FEMS microbiology …, 2022 - academic.oup.com
We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …
Apart from the fundamental interest in these defense systems, and revolutionary applications …
Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome
Bacteriophages have important roles in the ecology of the human gut microbiome but are
under-represented in reference databases. To address this problem, we assembled the …
under-represented in reference databases. To address this problem, we assembled the …
Expanding known viral diversity in the healthy infant gut
The gut microbiome is shaped through infancy and impacts the maturation of the immune
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …
system, thus protecting against chronic disease later in life. Phages, or viruses that infect …
The never-ending battle between lactic acid bacteria and their phages
Over the past few decades, the interest in lactic acid bacteria (LAB) has been steadily
growing. This is mainly due to their industrial use, their health benefits as probiotic bacteria …
growing. This is mainly due to their industrial use, their health benefits as probiotic bacteria …
Thousands of previously unknown phages discovered in whole-community human gut metagenomes
Background Double-stranded DNA bacteriophages (dsDNA phages) play pivotal roles in
structuring human gut microbiomes; yet, the gut virome is far from being fully characterized …
structuring human gut microbiomes; yet, the gut virome is far from being fully characterized …
Genome binning of viral entities from bulk metagenomics data
Despite the accelerating number of uncultivated virus sequences discovered in
metagenomics and their apparent importance for health and disease, the human gut virome …
metagenomics and their apparent importance for health and disease, the human gut virome …
Phage-inclusive profiling of human gut microbiomes with Phanta
Due to technical limitations, most gut microbiome studies have focused on prokaryotes,
overlooking viruses. Phanta, a virome-inclusive gut microbiome profiling tool, overcomes the …
overlooking viruses. Phanta, a virome-inclusive gut microbiome profiling tool, overcomes the …
Development of CRISPR-Cas systems for genome editing and beyond
F Zhang - Quarterly Reviews of Biophysics, 2019 - cambridge.org
The development of clustered regularly interspaced short-palindromic repeat (CRISPR)-Cas
systems for genome editing has transformed the way life science research is conducted and …
systems for genome editing has transformed the way life science research is conducted and …
[HTML][HTML] Infant gut DNA bacteriophage strain persistence during the first 3 years of life
Bacteriophages are key components of gut microbiomes, yet the phage colonization process
in the infant gut remains uncertain. Here, we establish a large phage sequence database …
in the infant gut remains uncertain. Here, we establish a large phage sequence database …
PhANNs, a fast and accurate tool and web server to classify phage structural proteins
For any given bacteriophage genome or phage-derived sequences in metagenomic data
sets, we are unable to assign a function to 50–90% of genes, or more. Structural protein …
sets, we are unable to assign a function to 50–90% of genes, or more. Structural protein …