[HTML][HTML] Recent advances in metabolomics analysis for early drug development
JC Alarcon-Barrera, S Kostidis, A Ondo-Mendez… - Drug discovery today, 2022 - Elsevier
Highlights•Metabolomics has become a widely applied tool in drug development.•
Metabolomics plays a key role for the identification of physiological response markers.• …
Metabolomics plays a key role for the identification of physiological response markers.• …
Recent advances in mass spectrometry-based computational metabolomics
The computational metabolomics field brings together computer scientists, bioinformaticians,
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …
chemists, clinicians, and biologists to maximize the impact of metabolomics across a wide …
The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry
H Mohammed Taha, R Aalizadeh, N Alygizakis… - Environmental Sciences …, 2022 - Springer
Abstract Background The NORMAN Association (https://www. norman-network. com/)
initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www. norman …
initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www. norman …
BUDDY: molecular formula discovery via bottom-up MS/MS interrogation
A substantial fraction of metabolic features remains undetermined in mass spectrometry
(MS)-based metabolomics, and molecular formula annotation is the starting point for …
(MS)-based metabolomics, and molecular formula annotation is the starting point for …
The changing metabolic landscape of bile acids–keys to metabolism and immune regulation
Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …
maintain gut microbial community composition and mediate inflammation, and they serve as …
LC/MS-based untargeted metabolomics analysis in women with morbid obesity and associated type 2 diabetes mellitus
Obesity is a chronic and complex disease, with an increasing incidence worldwide that is
associated with metabolic disorders such as type 2 diabetes mellitus (T2DM). Thus, it is …
associated with metabolic disorders such as type 2 diabetes mellitus (T2DM). Thus, it is …
Evaluation of data-dependent MS/MS acquisition parameters for non-targeted metabolomics and molecular networking of environmental samples: Focus on the Q …
Non-targeted liquid chromatography–tandem mass spectrometry (LC–MS/MS) is a widely
used tool for metabolomics analysis, enabling the detection and annotation of small …
used tool for metabolomics analysis, enabling the detection and annotation of small …
Metabolic flux between organs measured by arteriovenous metabolite gradients
Mammalian organs convert dietary nutrients into circulating metabolites and share them to
maintain whole-body metabolic homeostasis. While the concentrations of circulating …
maintain whole-body metabolic homeostasis. While the concentrations of circulating …
MetaboAnalystR 4.0: a unified LC-MS workflow for global metabolomics
The wide applications of liquid chromatography-mass spectrometry (LC-MS) in untargeted
metabolomics demand an easy-to-use, comprehensive computational workflow to support …
metabolomics demand an easy-to-use, comprehensive computational workflow to support …
[HTML][HTML] Acute aerobic exercise reveals that FAHFAs distinguish the metabolomes of overweight and normal-weight runners
AB Nelson, LS Chow, DB Stagg, JR Gillingham… - JCI insight, 2022 - ncbi.nlm.nih.gov
Background Responses of the metabolome to acute aerobic exercise may predict maximum
oxygen consumption (VO 2 max) and longer-term outcomes, including the development of …
oxygen consumption (VO 2 max) and longer-term outcomes, including the development of …