Maximizing the Accuracy of Equilibrium Dissociation Constants for Affinity Complexes: From Theory to Practical Recommendations
The equilibrium dissociation constant (K d) is a major characteristic of affinity complexes and
one of the most frequently determined physicochemical parameters. Despite its significance …
one of the most frequently determined physicochemical parameters. Despite its significance …
Recent advances in computational and experimental protein-ligand affinity determination techniques
V Kairys, L Baranauskiene… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Modern drug discovery revolves around designing ligands that target the
chosen biomolecule, typically proteins. For this, the evaluation of affinities of putative ligands …
chosen biomolecule, typically proteins. For this, the evaluation of affinities of putative ligands …
Determination of the binding constants and ionic mobilities of diquat complexes with randomly sulfated cyclodextrins by affinity capillary electrophoresis
J Bílek, D Koval, V Šolínová, HR Talele… - Journal of …, 2024 - Wiley Online Library
The enantiomers of diquats (DQs), a new class of functional organic molecules, were
recently separated by capillary electrophoresis (CE) with high resolution up to 11.4 within 5 …
recently separated by capillary electrophoresis (CE) with high resolution up to 11.4 within 5 …
Sensitivity enhancement of capillary electrophoresis‐frontal analysis‐based method for characterization of drug‐protein interactions using on‐line sample …
T Bržezická, Z Glatz, L Kohútová - Journal of Separation …, 2023 - Wiley Online Library
Capillary electrophoresis‐frontal analysis is one of the most frequently used approaches for
the study of plasma protein‐drug interactions as a substantial part of new drug development …
the study of plasma protein‐drug interactions as a substantial part of new drug development …
Constructing the Enamel-Like Dentin Adhesion Interface to Achieve Durable Resin–Dentin Adhesion
Y Li, J Dong, W Zhan, Y Shao, J Zhu, N Sun, N Dong… - ACS …, 2024 - ACS Publications
Enamel adhesion is acknowledged as durable; however, achieving long-lasting dentin
adhesion remains a formidable challenge due to degradation of exposed collagen matrix …
adhesion remains a formidable challenge due to degradation of exposed collagen matrix …
VPS26 Moonlights as a β-Arrestin-like Adapter for a 7-Transmembrane RGS Protein in Arabidopsis thaliana
Extracellular signals perceived by 7-transmembrane (7TM)-spanning receptors initiate
desensitization that involves the removal of these receptors from the plasma membrane …
desensitization that involves the removal of these receptors from the plasma membrane …
[HTML][HTML] Determination of the critical aggregation concentration in water of Gum Arabic functionalized with curcumin oxidation products by micro-scale thermophoresis …
Gum Arabic underwent enzymatic modification with curcumin oxidation products, prompting
self-assembly in water at lower concentrations than native gum Arabic, which was fully …
self-assembly in water at lower concentrations than native gum Arabic, which was fully …
Exploring the Binding Affinity of the ARR2 GARP DNA Binding Domain via Comparative Methods
J Rieger, M Fitz, SM Fischer, N Wallmeroth… - Genes, 2023 - mdpi.com
Plants have evolved signaling mechanisms such as the multi-step phosphorelay (MSP) to
respond to different internal and external stimuli. MSP responses often result in gene …
respond to different internal and external stimuli. MSP responses often result in gene …
Determination of physicochemical parameters of (bio) molecules and (bio) particles by capillary electromigration methods
S Štěpánová, V Kašička - Journal of Separation Science, 2024 - Wiley Online Library
The review provides an overview of recent developments and applications of capillary
electromigration (CE) methods for the determination of important physicochemical …
electromigration (CE) methods for the determination of important physicochemical …
Contactless conductivity detector as a tool for improving universality and sensitivity of capillary electrophoresis‐frontal analysis: Proof of concept
T Bržezická, H Mlčochová, Z Glatz… - Journal of Separation …, 2024 - Wiley Online Library
Drug binding to plasma proteins influences processes such as liberation, adsorption,
disposition, metabolism, and elimination of drugs, which are thus one of the key steps of a …
disposition, metabolism, and elimination of drugs, which are thus one of the key steps of a …