Gastroenteropancreatic neuroendocrine tumors

M Cives, JR Strosberg - CA: a cancer journal for clinicians, 2018 - Wiley Online Library
Neuroendocrine tumors (NETs) are heterogeneous malignancies arising from the diffuse
neuroendocrine system. They frequently originate in the gastroenteropancreatic (GEP) tract …

[HTML][HTML] Nothing but NET: a review of neuroendocrine tumors and carcinomas

B Oronsky, PC Ma, D Morgensztern, CA Carter - Neoplasia, 2017 - Elsevier
This review covers the diverse topic of neuroendocrine neoplasms (NENs), a relatively rare
and heterogeneous tumor type, comprising~ 2% of all malignancies, with a prevalence of< …

177Lu-Dotatate plus long-acting octreotide versus high‑dose long-acting octreotide in patients with midgut neuroendocrine tumours (NETTER-1): final overall survival …

JR Strosberg, ME Caplin, PL Kunz… - The Lancet …, 2021 - thelancet.com
Background The primary analysis of the phase 3 NETTER-1 trial showed significant
improvement in progression-free survival with 177 Lu-Dotatate plus long-acting octreotide …

[HTML][HTML] Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

M Pavel, K Öberg, M Falconi, EP Krenning, A Sundin… - Annals of …, 2020 - Elsevier
Neuroendocrine neoplasms (NENs) arise from the diffuse neuroendocrine cell system and
may occur at many different disease sites. Most frequently, these neoplasms occur in the …

[HTML][HTML] Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors

J Strosberg, G El-Haddad, E Wolin… - … England Journal of …, 2017 - Mass Medical Soc
Background Patients with advanced midgut neuroendocrine tumors who have had disease
progression during first-line somatostatin analogue therapy have limited therapeutic options …

Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled …

JC Yao, N Fazio, S Singh, R Buzzoni, C Carnaghi… - The Lancet, 2016 - thelancet.com
Background Effective systemic therapies for patients with advanced, progressive
neuroendocrine tumours of the lung or gastrointestinal tract are scarce. We aimed to assess …

ENETS consensus guidelines update for the management of distant metastatic disease of intestinal, pancreatic, bronchial neuroendocrine neoplasms (NEN) and NEN …

M Pavel, D O''Toole, F Costa, J Capdevila… - …, 2016 - karger.com
M. Pavel a D. O'Toole b F. Costa c J. Capdevila d D. Gross e R. Kianmanesh f E. Krenning g
U. Knigge h R. Salazar i U.-F. Pape a K. Öberg j all other Vienna Consensus Conference …

NCCN guidelines insights: neuroendocrine and adrenal tumors, version 2.2018

MH Shah, WS Goldner, TR Halfdanarson… - Journal of the National …, 2018 - jnccn.org
The NCCN Guidelines for Neuroendocrine and Adrenal Tumors provide recommendations
for the management of adult patients with neuroendocrine tumors (NETs), adrenal gland …

[HTML][HTML] Lanreotide in metastatic enteropancreatic neuroendocrine tumors

ME Caplin, M Pavel, JB Ćwikła, AT Phan… - … England Journal of …, 2014 - Mass Medical Soc
Background Somatostatin analogues are commonly used to treat symptoms associated with
hormone hypersecretion in neuroendocrine tumors; however, data on their antitumor effects …

[HTML][HTML] Targeting PI3K/Akt/mTOR signaling in cancer

C Porta, C Paglino, A Mosca - Frontiers in oncology, 2014 - frontiersin.org
The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin
(mTOR) signaling pathways are two pathways crucial to many aspects of cell growth and …