[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness
AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …
Lipid droplet biogenesis and functions in health and disease
Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …
Innate immune evasion strategies of SARS-CoV-2
JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …
SARS-CoV-2 biology and host interactions
S Steiner, A Kratzel, GT Barut, RM Lang… - Nature Reviews …, 2024 - nature.com
The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …
SARS-CoV-2 nsp3 and nsp4 are minimal constituents of a pore spanning replication organelle
L Zimmermann, X Zhao, J Makroczyova… - Nature …, 2023 - nature.com
Coronavirus replication is associated with the remodeling of cellular membranes, resulting
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …
in the formation of double-membrane vesicles (DMVs). A DMV-spanning pore was identified …
Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA. 1 variant through NSP6
Abstract Although the SARS-CoV-2 Omicron variant (BA. 1) spread rapidly across the world
and effectively evaded immune responses, its viral fitness in cell and animal models was …
and effectively evaded immune responses, its viral fitness in cell and animal models was …
Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA. 5
B Imbiakha, S Ezzatpour, DW Buchholz, J Sahler… - Science …, 2023 - science.org
Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …
The NSP4 T492I mutation increases SARS-CoV-2 infectivity by altering non-structural protein cleavage
X Lin, Z Sha, J Trimpert, D Kunec, C Jiang, Y Xiong… - Cell Host & Microbe, 2023 - cell.com
The historically dominant SARS-CoV-2 Delta variant and the currently dominant Omicron
variants carry a T492I substitution within the non-structural protein 4 (NSP4). Based on in …
variants carry a T492I substitution within the non-structural protein 4 (NSP4). Based on in …
Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …
infection has become a global pandemic due to the high viral transmissibility and …