Metformin is an oral antihyperglycemic drug widely used to treat type 2 diabetes mellitus
(T2DM), acting via indirect activation of 5′ Adenosine monophosphate-activated Protein …

Autophagy is an evolutionarily ancient mechanism that ensures the lysosomal degradation
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …

Metformin, as the basic pharmacological therapy and the first preventive drug in type 2
diabetes mellitus (T2DM), is proved to have potential protection in diabetic kidney disease …

Water pollution caused by widely used agricultural pesticide chlorpyrifos (CPF) has aroused
extensive public concern. While previous studies have reported on toxic effect of CPF on …

Oxidative stress can induce occurrence of non-alcoholic fatty liver disease (NAFLD). Nrf2 is
a central regulator of cellular oxidative stress and also participates in the control of lipid …

The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine
kinase, which senses and integrates several intracellular and environmental cues to …

Oxidative stress is a well-known driver of numerous pathological processes involving protein
and lipid peroxidation and DNA damage. The resulting increase of pro-apoptotic pressure …

The purpose of this study is to study the neuroprotective role of selective serotonin reuptake
inhibitor (SSRI), citalopram, against Alzheimer's disease (AD). Multiple SSRIs, including …

Background Colorectal cancer (CRC) is one of the most common aggressive malignancies.
LACTB functions as a tumor suppressor, and previous findings have demonstrated that …

In this investigation, a series of piperazine sulfynol derivatives 5 (al) were synthesized and
amply characterized by various spectral techniques viz, LC-MS, 1 H NMR, 13 C NMR, and …