Diabetic nephropathy (DN), one of the most common and intractable microvascular
complications of diabetes, is the main cause of terminal renal disease globally. MicroRNA …

An intricate interplay between genetic and environmental factors contributes to the
development of type 2 diabetes (T2D) and its complications. Therefore, it is not surprising …

The potential utility of microRNAs (miRNAs) as diagnostic or prognostic biomarkers, as well
as therapeutic targets, for chronic kidney disease (CKD) has been advocated. However …

Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is
driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients …

In diabetes, possibly the most significant site of microvascular damage is the kidney. Due to
diabetes and/or other co-morbidities, such as hypertension and age-related nephron loss, a …

Background T helper (Th) 9 cells are a novel subset of Th cells that develop independently
from Th2 cells and are characterized by the secretion of interleukin (IL)-9. Studies have …

Childhood obesity carries an increased risk of metabolic complications, sleep disturbances,
and cancer. Visceral adiposity is independently associated with inflammation and insulin …

Kidney fibrosis is one of the complications of chronic kidney disease (CKD (and contributes
to end-stage renal disease which requires dialysis and kidney transplantation. Several …

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder with severe
comorbidities. A multiomics approach can facilitate the identification of novel therapeutic …

Diabetic nephropathy (DN) is characterized by an increase in urinary albumin excretion,
diabetic glomerular lesions, and a decline in glomerular filtration rate (GFR). We assessed …