The complexity of the blood–brain barrier (BBB) and neurovascular unit (NVU) was and still
is a challenge to bridge. A highly selective, restrictive and dynamic barrier, formed at the …

Neutrophils, the most abundant white blood cells in circulation, are closely related to cancer
development and progression. Healthy primary neutrophils present potent cytotoxicity …

The lineage relationships of cells provide information about the origins of component cell
types during development and repair as well as the source of aberrant cells during disease …

In embryonic stem cell (ESC) models for early development, spatially and temporally varying
patterns of signaling and cell types emerge spontaneously. However, mechanistic insight …

Ischemic brain injury (IBI) is a common acute cerebral vessel disease that occurs secondary
to blockage in arteries, mainly characterized by insufficient blood supply to the brain. The …

Mitchell-Riley syndrome (MRS) is caused by recessive mutations in the regulatory factor X6
gene (RFX6) and is characterised by pancreatic hypoplasia and neonatal diabetes. To …

Precise insertion of fluorescent proteins into lineage-specific genes in human pluripotent
stem cells (hPSCs) presents challenges due to low knockin efficiency and difficulties in …

Proper cell‐cycle progression is essential for the self‐renewal and differentiation of human
pluripotent stem cells (hPSCs). The fluorescent ubiquitination‐based cell‐cycle indicator …

The emergence of several cell therapy candidates in the clinic is an encouraging sign for
human diseases/disorders that currently have no effective treatment; however, scalable …

Background: Cellular transplantation has emerged as promising approach for treating
cardiac diseases. However, a poor engraftment rate limits our understanding on how …