Restoring function after spinal cord injury: towards clinical translation of experimental strategies

LM Ramer, MS Ramer, EJ Bradbury - The Lancet Neurology, 2014 - thelancet.com
Spinal cord injury is currently incurable and treatment is limited to minimising secondary
complications and maximising residual function by rehabilitation. Improved understanding of …

Neurogenesis after spinal cord injury: state of the art

R Rodríguez-Barrera, M Rivas-González… - Cells, 2021 - mdpi.com
Neurogenesis in the adult state is the process of new neuron formation. This relatively
infrequent phenomenon comprises four stages: cell proliferation, cell migration …

Selenium nanoparticles derived from Proteus mirabilis YC801 alleviate oxidative stress and inflammatory response to promote nerve repair in rats with spinal cord …

X Liu, Y Mao, S Huang, W Li, W Zhang… - Regenerative …, 2022 - academic.oup.com
Microbial biotransformation and detoxification of biotoxic selenite into selenium
nanoparticles (SeNPs) has emerged as an efficient technique for the utilization of selenium …

What are the best animal models for testing early intervention in cerebral palsy?

GJ Clowry, R Basuodan, F Chan - Frontiers in neurology, 2014 - frontiersin.org
Interventions to treat cerebral palsy should be initiated as soon as possible in order to
restore the nervous system to the correct developmental trajectory. One drawback to this …

The evidence against somatotopic organization of function in the primate corticospinal tract

RN Lemon, RJ Morecraft - Brain, 2023 - academic.oup.com
We review the spatial organization of corticospinal outputs from different cortical areas and
how this reflects the varied functions mediated by the corticospinal tract. A long-standing …

Motor patterns of patients with spinal muscular atrophy suggestive of sensory and corticospinal contributions to the development of locomotor muscle synergies

VCK Cheung, SCW Ha… - Journal of …, 2024 - journals.physiology.org
Complex locomotor patterns are generated by combination of muscle synergies. How
genetic processes, early sensorimotor experiences, and the developmental dynamics of …

Animal models of developmental motor disorders: parallels to human motor dysfunction in cerebral palsy

CF Cavarsan, MA Gorassini… - Journal of …, 2019 - journals.physiology.org
Cerebral palsy (CP) is the most common motor disability in children. Much of the previous
research on CP has focused on reducing the severity of brain injuries, whereas very few …

[HTML][HTML] Plasticity of motor network and function in the absence of corticospinal projection

Q Han, C Cao, Y Ding, KF So, W Wu, Y Qu… - Experimental neurology, 2015 - Elsevier
Despite the obvious clinical interest, our understanding of how developmental mechanisms
are redeployed during degeneration and regeneration after brain and spinal cord injuries …

Conditional Loss of Arx From the Developing Dorsal Telencephalon Results in Behavioral Phenotypes Resembling Mild Human ARX Mutations

JC Simonet, CN Sunnen, J Wu, JA Golden… - Cerebral …, 2015 - academic.oup.com
Abstract Mutations in the Aristaless-Related Homeobox (ARX) gene cause structural
anomalies of the brain, epilepsy, and neurocognitive deficits in children. During forebrain …

Altered motoneuron properties contribute to motor deficits in a rabbit hypoxia-ischemia model of cerebral palsy

PR Steele, CF Cavarsan, L Dowaliby… - Frontiers in cellular …, 2020 - frontiersin.org
Cerebral palsy (CP) is caused by a variety of factors attributed to early brain damage,
resulting in permanently impaired motor control, marked by weakness and muscle stiffness …