The present article provides an up‐to‐date review summarizing almost 18 years of research
in genetically selected Marchigian Sardinian alcohol‐preferring (msP) rats. The results of …

Carboxypeptidase E (CPE) or carboxypeptidase H was first discovered in 1982 as an
enkephalin-convertase that cleaved a C-terminal basic residue from enkephalin precursors …

Tumor suppressor genes regulate cell growth and prevent spontaneous proliferation that
could lead to aberrant tissue function. Deletions and mutations of these genes typically lead …

The identification of genetic variants responsible for behavioral variation is an enduring goal
in biology, with wide-scale ramifications, ranging from medical research to evolutionary …

Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first
identified more than a quarter of a century ago as a gene up-regulated in rat hippocampus …

Wfs1-deficient mice were generated by disrupting the 8th exon of Wfs1 gene. Reproduction
rates of homozygous Wfs1-deficient mice were slightly below the expected values, they …

Mice lacking Carboxypeptidase E (CPE) exhibit degeneration of hippocampal neurons
caused by stress at weaning while over-expression of CPE in hippocampal neurons protect …

Metabotropic glutamate receptor subtype 5 (mGluR5), encoded by the GRM5 gene,
represents a compelling novel drug target for the treatment of schizophrenia. mGluR5 is a …

Bipolar disorder (BD) is a common, complex and heritable psychiatric disorder characterized
by episodes of severe mood swings. The identification of rare, damaging genomic mutations …

Carboxypeptidase E, also known as neurotrophic factor-α1 (CPE-NFα1), was first
discovered as an exopeptidase and is known to work by cleaving C-terminal basic amino …