In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …

Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

The mammalian brain consists of millions to billions of cells that are organized into many cell
types with specific spatial distribution patterns and structural and functional properties …

The hypothalamus plays a key role in coordinating fundamental body functions. Despite
recent progress in single-cell technologies, a unified catalog and molecular characterization …

Human brain organoids represent remarkable platforms for recapitulating features of human
brain development and diseases. Existing organoid models do not resolve fine brain …

This review explores the interface between circadian timekeeping and the regulation of
brain function by astrocytes. Although astrocytes regulate neuronal activity across many time …

Cellular circadian clocks direct a daily transcriptional program that supports homeostasis
and resilience. Emerging evidence has demonstrated age-associated changes in circadian …

Neurodegenerative diseases encompass a large group of conditions that are clinically and
pathologically diverse yet are linked by a shared pathology of misfolded proteins. The …

The blood-brain barrier (BBB) is critical for neural function. We report here circadian
regulation of the BBB in mammals. Efflux of xenobiotics by the BBB oscillates in mice, with …

The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined
cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and …