Background: Sepsis/septic shock is a life-threatening and time-dependent condition that
requires timely management to reduce mortality. This review aims to update physicians with …

Abstract The Surviving Sepsis Campaign recommends immediate antibiotics for all patients
with suspected sepsis and septic shock, ideally within 1 hour of recognition. Immediate …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Background: Administering antimicrobial agents before obtaining blood cultures could
potentially decrease time to treatment and improve outcomes, but it is unclear how this …

Importance Although inadequate sleep has a proven negative association with health care
outcomes, to date, no large-scale studies have examined sleep in general hospital wards …

Background: Successful integrations of machine learning into routine clinical care are
exceedingly rare, and barriers to its adoption are poorly characterized in the literature …

Abstract The Centers for Medicare & Medicaid Services' Severe Sepsis and Septic Shock
Early Management Bundle (SEP-1) measure has appropriately established sepsis as a …

Sepsis is medicine's last remaining preserve for unrestrainedantibioticprescribing.
TheSurvivingSepsisCampaign guidelines recommend empirical broadspectrum therapy …

Background Effective antimicrobial treatment is key for survival in bloodstream infection
(BSI), but the impact of timing of treatment remains unclear. Our aim was to assess the …

Patients with sepsis present across a spectrum of infection sites and severity of illnesses
requiring complex decision making at the bedside as to when prompt antibiotics are …