Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

Genetic information is translated into proteins by the ribosome. Structural studies of the
ribosome and of its complexes with factors and inhibitors have provided invaluable …

Protein synthesis occurs on macromolecular machines, called ribosomes. Bacterial
ribosomes and the translational machinery represent one of the major targets for antibiotics …

With bacterial resistance becoming a serious threat to global public health, antimicrobial
peptides (AMPs) have become a promising area of focus in antibiotic research. AMPs are …

SUMMARY In his 2001 article,“Translation: in retrospect and prospect,” the late Carl Woese
made a prescient observation that there was a need for the then-current view of translation …

Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …

Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …

Many Proteobacteria use quorum sensing to regulate production of public goods, such as
antimicrobials and proteases, that are shared among members of a community. Public …

Protein synthesis is a major target within the bacterial cell for antibiotics. Investigations into
ribosome-targeting antibiotics have provided much needed functional and structural insight …

Species of Burkholderia are highly versatile being found not only abundantly in soil, but also
as plants and animals' commensals or pathogens. Their complex multireplicon genomes …