Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all
BA Desimmie, KA Delviks-Frankenberrry… - Journal of molecular …, 2014 - Elsevier
Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers
SA Roberts, MS Lawrence, LJ Klimczak, SA Grimm… - Nature …, 2013 - nature.com
Recent studies indicate that a subclass of APOBEC cytidine deaminases, which convert
cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may …
cytosine to uracil during RNA editing and retrovirus or retrotransposon restriction, may …
Genetic alterations in esophageal tissues from squamous dysplasia to carcinoma
X Liu, M Zhang, S Ying, C Zhang, R Lin, J Zheng… - Gastroenterology, 2017 - Elsevier
Background & Aims Esophageal squamous cell carcinoma (ESCC) is the most common
subtype of esophageal cancer. Little is known about the genetic changes that occur in …
subtype of esophageal cancer. Little is known about the genetic changes that occur in …
RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing
HC Smith - RNA biology, 2017 - Taylor & Francis
ABSTRACT Apolipoprotein B mRNA Editing Catalytic Polypeptide-like 1 or APOBEC1 was
discovered in 1993 as the zinc-dependent cytidine deaminase responsible for the …
discovered in 1993 as the zinc-dependent cytidine deaminase responsible for the …
Remarkable Lethal G-to-A Mutations in vif-Proficient HIV-1 Provirus by Individual APOBEC3 Proteins in Humanized Mice
Genomic hypermutation of RNA viruses, including human immunodeficiency virus type 1
(HIV-1), can be provoked by intrinsic and extrinsic pressures, which lead to the inhibition of …
(HIV-1), can be provoked by intrinsic and extrinsic pressures, which lead to the inhibition of …
The current structural and functional understanding of APOBEC deaminases
R Bransteitter, C Prochnow, XS Chen - Cellular and molecular life …, 2009 - Springer
The apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of
cytidine deaminases has emerged as an intensively studied field as a result of their …
cytidine deaminases has emerged as an intensively studied field as a result of their …
Structural insights into APOBEC3-mediated lentiviral restriction
KA Delviks-Frankenberry, BA Desimmie, VK Pathak - Viruses, 2020 - mdpi.com
Mammals have developed clever adaptive and innate immune defense mechanisms to
protect against invading bacterial and viral pathogens. Human innate immunity is …
protect against invading bacterial and viral pathogens. Human innate immunity is …
Clustered and genome‐wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness
SA Roberts, DA Gordenin - Bioessays, 2014 - Wiley Online Library
The gain of a selective advantage in cancer as well as the establishment of complex traits
during evolution require multiple genetic alterations, but how these mutations accumulate …
during evolution require multiple genetic alterations, but how these mutations accumulate …
Nanoscale structure and dynamics of ABOBEC3G complexes with single-stranded DNA
LS Shlyakhtenko, AY Lushnikov, A Miyagi, M Li… - Biochemistry, 2012 - ACS Publications
The DNA cytosine deaminase APOBEC3G (A3G) is capable of blocking retrovirus
replication by editing viral cDNA and impairing reverse transcription. However, the …
replication by editing viral cDNA and impairing reverse transcription. However, the …